Osteoarthritis is the most common joint disease around the world. Approximately 20 million individuals in the United States have osteoarthritis, but estimates vary from country to country. With such a high prevalence overall, osteoarthritis incurs significant costs to the individual patient and to the population at large.
Pathophysiology and Risk Factors
Osteoarthritis involves progressive degeneration of joint cartilage with proliferation of bone. Multiple factors are involved in the disease process, including genetics, local inflammation, joint integrity, mechanical forces, and cellular processes. Of the risk factors for osteoarthritis, age is one of the strongest with the disease starting as early as age 45. Being female and/or obesity may also increase the risk for osteoarthritis.
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